Hey Guyz,
Please post your questions regarding toxicology here (as we did with community). We want all the questions in one basket...errr...post!!
Thanks, and study hard!!
Re: Questions Corner By: dr_yoyo Date: May 29, 2006, 02:26:03 AM
hi doctors,
i want last year exam (DOR TANY)
Re: Questions Corner By: einstein Date: May 29, 2006, 09:58:59 PM
please Dr Samar:
1-what are the indications of ABG as an investigation: changes in PO2 & PCO2 only or change in PH also?
2-in doing the ABG in case of CO poisoning, will we find both PO2 & PCO2 elevated?
3-in our toxicology book, it is mentioned that the toxicity of H2S is due to its binding & inhibition of cytochrome oxidase, just as for cyanide, so how come there is cyanosis of the skin in case of H2S & red color of the skin in case of CO?
NB.in the community book it is mentioned that the mechanism of toxicity of H2S is the CNS depression of Respiratory center, I do not know which mechnism is the right one?
Re: Questions Corner By: princess_ami Date: May 30, 2006, 01:24:40 AM
ok Enistien i found these thing for u :
when to consider ABG measurement ?
in these critical scenarios :
-any unexpected deteriration in an ill patient
- anyone with acute exacerbation of a chronic chest condition
- anyone with impaired consciousness
- anyone with impaired respiratory effort
or if any of these signs and symptoms are present :
bounding pulse , drowsy , tremors , headache, pink palms , papillodema ( sighns of CO2 retention )
cyanosis , confusion , visual hallucination ( signs of hypoxia )
it includes :
PH
PaCO2
PaO2
Base excess
that's enough for that
Re: Questions Corner By: drsamar Date: May 30, 2006, 10:39:22 AM
ok einstein take care the red colour in CO is due to the carboxy hemoglobin formation. carboxy hb is red in colour and u tend to see that thru the skin. as for h2s no co is formed and the only problem is that cytochrom oxidase is not functioning and so there is no utilization of oxygen so ther is asphyxia histotoxic type and thus cyanosis
Re: Questions Corner By: einstein Date: May 30, 2006, 04:16:13 PM
thx Dr Samar, but what i was thinking of is that both CO & H2S do not affect the level of oxyhemoglobin which is red in color so the skin may be red in both & hence i asked if the PO2 in both does not change, am i right?
Re: Questions Corner By: drsamar Date: May 30, 2006, 06:14:37 PM
co replaces the oxygen in the oxyhemoglobin and transforms it into carboxyhemoglobin so how come wont it affect the oxy hb?
Re: Questions Corner By: drkimo Date: May 30, 2006, 07:41:00 PM
co replaces the oxygen in the oxyhemoglobin and transforms it into carboxyhemoglobin so how come wont it affect the oxy hb?
i heard too,tht the O2 which couldnt bind wth Hb in case of CO poisoning dissolves in the plasma So, the PaO2 is not changed. but the oxyHb decreases... So NO changes in the ABG
Is that Right??
Re: Questions Corner By: drsamar Date: May 30, 2006, 08:24:49 PM
true kimo and i am glad u are nobody
Re: Questions Corner By: I-queless Date: May 30, 2006, 09:50:24 PM
what does the renal test "BUN" stand for?
also the liver function tests "SGOT" and "SGPT"?
Re: Questions Corner By: ahmedfathalla Date: May 30, 2006, 10:24:28 PM
i think that the "U" is for urea and "N" for nitrogen
Re: Questions Corner By: drkimo Date: May 30, 2006, 11:25:14 PM
thnx Dr.
BUN>>blood,urea and nitrogen >>renal function tests.
sGPT,sGOT>>liver enzymes elevated in the liver dysfunction(iron,paracetamol and zinc phosphide)
*all have liver toxicity
*all have stages in their C/P
*liver symptoms in stage III
*all need liver support(vitK,B,,salt free albumin,Glucose)
grouping to most imp. drugs..Re: Questions Corner By: I-queless Date: May 31, 2006, 12:44:39 AM
thanks a lot
Re: Questions Corner By: einstein Date: May 31, 2006, 09:59:29 PM
what about cyanide toxicity Dr Samar, why the skin is red in color?
Re: Questions Corner By: drsamar Date: May 31, 2006, 11:38:15 PM
because cyanomethemoglobin is brick red in colour